Michael J Edwards Selected Research

Amitriptyline (Elavil)

1/2021	The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain Injury.
11/2020	Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
1/2020	Acid Sphingomyelinase Inhibition Mitigates Histopathological and Behavioral Changes in a Murine Model of Traumatic Brain Injury.
12/2019	Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
1/2017	Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.
1/2016	Role of Janus-Kinases in Major Depressive Disorder.
1/2016	Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.
6/2015	Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
3/2015	Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice.

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Michael J Edwards Research Topics

Disease

21	Infections 01/2021 - 01/2014
19	Neoplasms (Cancer) 05/2022 - 09/2002
15	Ischemia 01/2016 - 04/2002
13	Inflammation (Inflammations) 11/2020 - 04/2002
12	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 05/2013
11	Melanoma (Melanoma, Malignant) 04/2016 - 01/2002
10	Breast Neoplasms (Breast Cancer) 03/2014 - 04/2002
9	Neoplasm Metastasis (Metastasis) 06/2015 - 01/2002
8	Reperfusion Injury 01/2016 - 04/2002
7	Pneumonia (Pneumonitis) 11/2021 - 01/2014
7	Bacterial Infections (Bacterial Infection) 11/2020 - 01/2015
4	Adenocarcinoma 05/2022 - 12/2002
4	Major Depressive Disorder (Major Depressive Disorders) 01/2022 - 01/2015
4	Fibrosis (Cirrhosis) 03/2015 - 07/2011
3	Wounds and Injuries (Trauma) 01/2021 - 03/2010
3	Edema (Dropsy) 01/2018 - 01/2006
2	Ventilator-Associated Pneumonia 11/2021 - 01/2019
2	Pseudomonas Infections 01/2021 - 12/2016
2	Vesicular Stomatitis 01/2021 - 11/2020
2	Virus Diseases (Viral Diseases) 11/2020 - 11/2020
2	COVID-19 11/2020 - 11/2020
2	Burns 10/2020 - 12/2016
2	Pancreatitis 01/2017 - 10/2014
2	Abdominal Pain (Pain, Abdominal) 10/2016 - 10/2015
2	Chronic Pancreatitis 10/2016 - 10/2015
2	End Stage Liver Disease 04/2016 - 05/2013
2	Sepsis (Septicemia) 06/2015 - 01/2015
2	Liver Diseases (Liver Disease) 03/2015 - 05/2013
2	Fibroadenoma 10/2005 - 09/2004
1	Brain Concussion (Cerebral Concussion) 01/2021
1	Mental Disorders (Mental Disorder) 01/2021
1	Soft Tissue Infections 11/2020
1	Surgical Wound Infection 11/2020
1	Critical Illness (Critically Ill) 10/2020
1	Neuroinflammatory Diseases 01/2020

Drug/Important Bio-Agent (IBA)

21	CeramidesIBA 01/2022 - 05/2013
16	SphingosineIBA 01/2021 - 09/2014
16	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2021 - 05/2013
15	AcidsIBA 01/2021 - 05/2013
9	Amitriptyline (Elavil)FDA LinkGeneric 01/2021 - 03/2015
7	Anti-Bacterial Agents (Antibiotics)IBA 11/2021 - 01/2015
5	Acid CeramidaseIBA 01/2021 - 09/2014
5	SphingolipidsIBA 11/2018 - 06/2015
5	CXC ChemokinesIBA 04/2015 - 10/2008
4	Antidepressive Agents (Antidepressants)IBA 11/2020 - 01/2015
4	CytokinesIBA 01/2014 - 08/2009
4	NF-kappa B (NF-kB)IBA 03/2012 - 07/2002
3	Pharmaceutical PreparationsIBA 05/2022 - 11/2020
3	LipidsIBA 11/2021 - 01/2015
3	Phenobarbital (Luminal)FDA Link 01/2021 - 09/2014
3	EnzymesIBA 11/2020 - 05/2013
3	LigandsIBA 06/2017 - 03/2012
2	Potassium Channels (Potassium Channel)IBA 05/2022 - 01/2017
2	Expectorants (Mucolytics)IBA 11/2021 - 01/2021
2	SARS-CoV-2 spike proteinIBA 01/2021 - 11/2020
2	CalciumIBA 01/2020 - 01/2019
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2002
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2019 - 01/2016
2	PlasticsIBA 01/2019 - 04/2002
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 04/2016 - 06/2006
2	Progesterone Receptors (Progesterone Receptor)IBA 03/2014 - 09/2006
2	Transcription Factors (Transcription Factor)IBA 03/2012 - 05/2009
2	Hormones (Hormone)IBA 05/2010 - 03/2009
2	Biological ProductsIBA 03/2010 - 03/2004
2	Estrogen ReceptorsIBA 06/2008 - 06/2007
2	Technetium Tc 99m Sulfur Colloid FDA Link 06/2004 - 01/2002
2	Colloids (Colloid)IBA 01/2003 - 12/2002
2	Coloring Agents (Dyes)IBA 01/2003 - 01/2003
1	Gemcitabine FDA Link 05/2022
1	Albumin-Bound Paclitaxel FDA Link 05/2022
1	CyclohexanolsIBA 01/2021
1	interferon regulatory factor-8 (interferon consensus sequence binding protein)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2021
1	Ambroxol (Mucosolvan)IBA 01/2021
1	Maprotiline (Ludiomil)FDA Link 11/2020
1	Sertraline (Zoloft)FDA LinkGeneric 11/2020
1	Escitalopram FDA Link 11/2020
1	Imipramine (Janimine)FDA LinkGeneric 11/2020
1	Fluoxetine (Prozac)FDA LinkGeneric 11/2020
1	Saline SolutionIBA 11/2020
1	SiliconesIBA 11/2020
1	Doxycycline (Periostat)FDA LinkGeneric 11/2020

Therapy/Procedure

12	Therapeutics 06/2019 - 03/2003
8	Lymph Node Excision (Lymph Node Dissection) 04/2016 - 03/2002
3	Drug Therapy (Chemotherapy) 01/2019 - 12/2004
3	Pancreatectomy 01/2017 - 10/2014
2	Pancreaticoduodenectomy 10/2016 - 09/2014
2	Hepatectomy 01/2016 - 01/2015
2	Autologous Transplantation 10/2015 - 10/2014
2	Liver Transplantation 03/2015 - 07/2011
2	Transplantation 12/2011 - 02/2009
2	Ligation 08/2010 - 01/2006
2	Advanced Trauma Life Support Care 03/2010 - 04/2004
2	Radiotherapy 06/2008 - 01/2002
2	Cryosurgery 10/2005 - 09/2004
1	Artificial Respiration (Mechanical Ventilation) 11/2021
1	Mammaplasty (Breast Reconstruction) 11/2020
1	Breast Implants (Breast Implant) 11/2020
1	Replacement Arthroplasty 01/2020